2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ser/Thr Protease

Ser/Thr Protease

Serine proteases; Serine endopeptidases; Threonine proteases

Ser/Thr Protease

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Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W195509
    Debrisoquin hydroiodide
    		Inhibitor 99.84%
    Debrisoquin (hydroiodide) is the hydrochloride form of Debrisoquin (HY-B1624). Debrisoquin is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner. Debrisoquin can be used for antiviral research.
    Debrisoquin hydroiodide
  • HY-E70200
    Recombinant Kex2 protease
    Recombinant Kex2 protease is a membrane-bound, Ca2+-dependent serine protease. Recombinant Kex2 protease specifically recognize and cleave the carboxyl-terminal peptide bonds of dibasic amino acids.
    Recombinant Kex2 protease
  • HY-137814
    4-Nitrophenyl 4-guanidinobenzoate hydrochloride
    		99.38%
    4-Nitrophenyl 4-guanidinobenzoate (NPGB) hydrochloride is a potent sperm acrosin inhibitor, and also a trypsin substrate.
    4-Nitrophenyl 4-guanidinobenzoate hydrochloride
  • HY-101270
    STK16-IN-1
    		Inhibitor 99.81%
    STK16-IN-1 is a STK16 kinase inhibitor with an IC50 of 295 nM.
    STK16-IN-1
  • HY-108845
    Tenecteplase
    		Inhibitor
    Tenecteplase (TNK-tPA) is a modified tissue plasminogen activator. Tenecteplase is a recombinant human tissue plasminogen activator (rt-PA) that has been bioengineered to produce mutations in three gene loci. Tenecteplase (TNK-tPA) can be used in the study of acute ischemic stroke.
    Tenecteplase
  • HY-108447
    BC-11 hydrobromide
    		Inhibitor ≥99.0%
    BC-11 hydrobromide is a selective TMPRSS2 inhibitor (TMPRSS2 is a key host cellular factor for viral entry and SARS-CoV-2 pathogenesis), and a selective urokinase (uPA) inhibitor (IC50=8.2 μM). BC-11 hydrobromide is cytotoxic to triple-negative MDA-MB231 breast cancer cells. BC-11 hydrobromide is used in research on viral infections and cancer.
    BC-11 hydrobromide
  • HY-19303B
    CRA-2059 TFA
    		Inhibitor 99.62%
    CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ).
    CRA-2059 TFA
  • HY-114330A
    ZK824859 hydrochloride
    		Inhibitor 99.03%
    ZK824859 hydrochloride is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively.
    ZK824859 hydrochloride
  • HY-163690
    HTRA1-IN-1
    		Inhibitor
    HTRA1-IN-1 (Compound 17) is a selective inhibitor for serine protease high temperature requirement A serine peptidase 1 (HTRA1), with IC50 of 13 nM. HTRA1-IN-1 is potential for ameliorating HTRA1-related diseases, such as age-related macular degeneration (AMD), osteoarthritis, and rheumatoid arthritis.
    HTRA1-IN-1
  • HY-114080
    Patamostat
    		Inhibitor 98.13%
    Patamostat (E-3123) is a potent protease inhibitor. Patamostat potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat may possess suppressing effects on pathogenesis and development of acute pancreatitis.
    Patamostat
  • HY-N2028
    Demethylwedelolactone
    		99.89%
    Demethylwedelolactone is a naturally occurring coumestan isolated from Eclipta alba. Demethylwedelolactone is a potent trypsin inhibitor with an IC50 of 3.0 μM. Demethylwedelolactone suppresses cell motility and cell invasion of breast cancer cell.
    Demethylwedelolactone
  • HY-112688
    H-Arg-4MβNA
    		99.62%
    H-Arg-4MβNA is a substrate for cathepsin H, used for the detection of enzyme activity in gel electrophoresis.
    H-Arg-4MβNA
  • HY-147404A
    Tilpisertib fosmecarbil TFA
    		Inhibitor 98.05%
    Tilpisertib fosmecarbil TFA is the TFA salt form of Tilpisertib (HY-147404). Tilpisertib fosmecarbil TFA is an inhibitor for serine/threonine kinase. Tilpisertib fosmecarbil TFA has anti-inflammatory activity.
    Tilpisertib fosmecarbil TFA
  • HY-107759
    Butabindide oxalate
    		Inhibitor 98.98%
    Butabindide (UCL-1397) oxalate is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide oxalate inhibits TPP II to protect CCK-8 against inactivation.
    Butabindide oxalate
  • HY-P5994
    MeOSuc-AAPF-CMK
    		Inhibitor 98.65%
    MeOSuc-AAPF-CMK (MeOSuc-Ala-Ala-Pro-Phe-CH Cl) is a potent proteinase K inhibitor.
    MeOSuc-AAPF-CMK
  • HY-P1918
    Activated Protein C (390-404), human
    		99.01%
    Activated Protein C (390-404), human is a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity.
    Activated Protein C (390-404), human
  • HY-19727A
    FOY 251
    		Inhibitor 98.86%
    FOY 251, an anti-proteolytic active metabolite Camostate (HY-13512), acts as a proteinase inhibitor. FOY 251 inhibits SARS-CoV-2 infection in cells assay.
    FOY 251
  • HY-E70203
    Recombinant aprotinin
    		Inhibitor
    Recombinant aprotinin is a serine protease inhibitor. Recombinant aprotinin can inhibit trypsin and related proteolytic enzymes.
    Recombinant aprotinin
  • HY-156437
    NBI-961
    		Inhibitor 99.73%
    NBI-961 is a potent NEK2 inhibitor that inhibits proteasomal degradation. NBI-961 induces G2/mitosis arrest and apoptosis in diffuse large B cell lymphoma (DLBCL) cells.
    NBI-961
  • HY-156818
    TNIK-IN-7
    		Inhibitor 99.90%
    TNIK-IN-7 (Compound 8) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK), with IC50 of 11 nM, that has antitumor activity.
    TNIK-IN-7
Cat. No. Product Name / Synonyms Application Reactivity